The demand for fast disintegrating tablets (FDT) has been growing during the last decade especially for the children and the elder people who have swallowing difficulties. Lamivudine, a retroviral drug (2', 3'-dideoxy-3'- thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. Oral bioavailability of the drug is around 86% and having half life of 5-7 hrs. In the present investigation an attempt has been made to prepare fast disintegrating tablets of lamivudine by using super disintegrants like crospovidone, ludiflash along with novel co -processed excipients by direct compression method. Various formulations were prepared using different concentrations of superdisintegrant and coprocessed excipients. The pre and post compression parameters were evaluated for each formulation and the results were found satisfactory. The tablets containing crospovidone and co-processed excipient mixture ludiflash having total crospovidone concentration of 4.5% showed disintegration time, 16 sec and higher drug release of 96.33% in 30 min. It can be concluded that the usage of optimum concentration (4.5%) mixture of co-processed disintegrants were successful in developing lamivudine FDTs.
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